Jose Mourinho makes six changes to last weekend’s victory over Arsenal. Rashford leads the line with Lukaku injured, and he’s flanked by Mata and Martial, with Lingard and Sanchez replaced. Fellaini starts ahead of Herrera in midfield, while Darmian and Rojo get the nod in defense at the expense of Valencia and Lindelof.
SUBS: Luke Shaw, Jesse Lingard, Victor Lindelof, Scott McTominay, Eric Bailly, Sergio Romero, Ander Herrera.
SUBS: Connor Goldson, Leonardo Ulloa, Solly March, Tim Krul, Jurgen Locadia, Ezequiel Schelotto, Beram Kayal.
BRIGHTON (4-5-1): Mat Ryan; Bruno, Shane Duffy, Lewis Dunk, Gaetan Bong; Anthony Knockaert, Dale Stephens, Pascal Gross, Davy Propper, Jose Izquierdo; Glenn Murray.